Mixed phenotype acute leukemia with PML-RARα positive: a case report and literature review

Abstract Mixed phenotype acute leukemia (MPAL) is an uncommon type of leukemia. It one kind malignant clonal diseases that expresses more than genealogical specific antigen simultaneously. Most MPAL patients are associated with chromosomal abnormalities and molecular genetic changes, such as t(9;22) (q34;q11) KMT2A (MLL) rearrangement. These usually have important guiding significance in diagnosis, targeted therapy prognosis judgment. In this paper, we reported a case MPAL, T/myeloid (M5) unfrequent combination PML-RARα positivity t(15;17). The treatment was successful chemotherapy for both AML ALL daunorubicin, cytarabine (DA) vincristine, prednisone (VP). We here suggestive rare disease condition effective treatment, order to provide experience the early diagnosis similar patients.